Medical device companies in Minnesota: 312 manufacturing sites, 672 FDA registrations and where they are

This report is for people sizing Minnesota's device industry as a whole: suppliers and service firms deciding where to sell, job seekers outside the Twin Cities, economic developers and B2B sellers. For the metro alone, with its public-company table, see medical device companies in Minneapolis.

Minnesota against the other device states

County Business Patterns 2023, NAICS 3391 (medical equipment and supplies) plus 334510 (electromedical and electrotherapeutic apparatus), state of Minnesota:

Ranked by employees in the same state file, Minnesota is second, behind California (84,094) and ahead of Florida (23,486) and Massachusetts (21,489); that ranking is our calculation. The US employee and payroll totals are sums of the state figures.

In broader bands, 187 establishments have 1 to 19 employees, 61 have 20 to 99 and 64 have 100 or more. Seventeen have 500 or more.

What Minnesota makes

The ophthalmic employee count was published but flagged as high-noise (noise added for confidentiality moved it by 5% or more). The Census Bureau adds that noise separately to state and metro figures, so the state and Twin Cities numbers for one code don't always reconcile; the metro's instruments count, for example, comes out slightly above the state's. Dental laboratories are a quarter of the establishments but under 3% of the jobs, so strip them out of any list built on the Census code if you want device makers.

County Business Patterns counts establishments with paid employees, not companies, and leaves out the self-employed. A company's headquarters or research center may be classified outside these codes.

Where the FDA-registered sites are

Owners and operators of establishments that produce or distribute devices for the US market register each one with FDA every year. The weekly registration file of 25 October 2026 lists 672 Minnesota establishments belonging to 530 owner-operators.

County assigned from each registration's ZIP code. "Rest of the state" counts the other counties, including the Twin Cities metro's smaller ones.

Outside the Twin Cities metro there are 58 registrations, 44 of them manufacturers or contract manufacturers. Rochester has 15, St. Cloud 7 and Dassel 4, with Red Wing, Wabasha, Winona and Princeton at 2 each.

The largest owners

"Manufacturing" means the registration lists manufacturer or contract manufacturer among its activities.

The filings of two of these add context. Medtronic's 10-K says its principal executive office is in Ireland and its main operational offices are in the Minneapolis metro. Boston Scientific's 10-K, filed from Marlborough, Massachusetts, lists Minnesota among the locations of its principal manufacturing facilities and reports that it bought out leases on land and office and lab space in Maple Grove for $205 million in late 2025.

Minnesota-headquartered public device companies include Solventum (Maplewood, $8,325 million of 2025 net sales), Inspire Medical Systems (Golden Valley, $912.0 million), Tactile Systems Technology and CVRx in Minneapolis, and, outside the core metro, Electromed in New Prague, which reported $73.8 million of net revenue for the year to June 2026.

Selling to Minnesota device companies

The 64 large sites are where the volume is, but getting on an approved-supplier list means audits and first-article inspections. The 61 mid-sized sites move faster and are often contract manufacturers that serve the large ones.

Illustrative example. The company, prices and results are invented; the counts are from the FDA file.

Prairie Validation (prairievalidation.example) runs sterilization validation and package testing. It targets Minnesota's 224 registered contract manufacturers, keeps those whose listings include sterile devices, an illustrative 40% or about 90 sites, and contacts the quality manager and the operations director at each: 180 people, including the 44 manufacturing sites outside the metro that are a long drive from most labs. Six new clients a year at $50,000 is $300,000. Bebop can build that list from a plain description and research each site; for structuring it, see how to build a prospect list.

Subject: Validation turnaround for [company]'s sterile lines

Hi [first name],

[Company] is registered with FDA as a contract manufacturer in [city], and your customers will expect revalidation on every material or process change.

We run sterilization validation and package testing for Minnesota manufacturers, with on-site sampling across the state, so you aren't waiting on a lab two states away.

Could we price your next revalidation?

[Your name]

Where to look

Next step: see who the biggest device makers are nationally in the largest medical device companies.