Short answer
Florida had 184 pharmaceutical and medicine manufacturing establishments in 2023, employing 9,967 people at an average annual pay of $72,704 (Census County Business Patterns), third among states. 117 of them have fewer than 20 employees. The state also had 864 drug wholesale establishments with 15,829 employees. FDA's registration file lists 309 drug establishments in Florida, and the state's Drug and Cosmetic Act requires a separate permit for each type of drug business.
- Miami-Dade (38), Broward (30) and Palm Beach (20) counties hold 88 of Florida's 184 drug manufacturing establishments.
- Drug wholesale establishments (864) outnumber drug plants almost five to one and employ 15,829 people.
- By our count of firm names, 40 of the 218 manufacturing registrations in FDA's Florida file are medical gas suppliers.
- Ligand Pharmaceuticals now gives Jupiter, Florida, as its headquarters in its 10-K, with $268.1 million of 2025 revenue.
- Florida law lists 18 permit types, from prescription drug manufacturer to third party logistics provider.
On this page
This report is for job seekers, distributors, contract partners and B2B sellers looking at Florida's drug companies. It counts the plants from Census data, the registered sites from FDA's own file and the listed companies from their 10-Ks, explains Florida's permit system, and ends with a prospecting plan built for a market of small firms.
How many pharmaceutical companies are in Florida
County Business Patterns (CBP) 2023, NAICS 3254 (Pharmaceutical and Medicine Manufacturing), Florida:
| Measure (2023) | Florida |
|---|---|
| Establishments | 184 |
| Employees | 9,967 |
| Annual payroll | $724,643,000 |
| Average employees per establishment | 54.2 |
| Average annual pay | $72,704 |
| Share of US establishments | 6.34% of 2,901 |
| Rank among states by establishments | 3rd |
Remember that CBP counts locations with a payroll, not companies, and skips the self-employed. It classifies each location by its main activity, so Florida's large drug distribution trade sits in another code: 864 drug wholesale establishments (NAICS 424210) with 15,829 employees in 2023. Biotechnology R&D adds 236 establishments (NAICS 541714) with 2,726 employees. Corporate head offices land in a separate managing-offices code.
Small plants, mostly finished dose
| Employees per establishment | Establishments |
|---|---|
| 1 to 4 | 63 |
| 5 to 9 | 29 |
| 10 to 19 | 25 |
| 20 to 49 | 28 |
| 50 to 99 | 12 |
| 100 to 249 | 15 |
| 250 to 499 | 8 |
| 500 to 999 | 4 |
| 1,000 or more | 0 (derived) |
The Census Bureau doesn't publish the 1,000 or more cell for Florida; the published classes add up to the full 184, so the derived figure is zero. Almost two-thirds of the plants (117) have fewer than 20 employees, 40 have 20 to 99 and 27 have 100 or more.
By six-digit code, 104 make finished dose pharmaceuticals (6,876 employees), 51 make medicinal chemicals and botanicals (1,666), 19 make biologics (1,132) and 10 make in-vitro diagnostic substances (293).
| County | Establishments | Employees |
|---|---|---|
| Miami-Dade | 38 | 1,461 |
| Broward | 30 | 2,075 |
| Palm Beach | 20 | 1,182 |
| Hillsborough | 18 | 1,141 |
| Pinellas | 15 | 1,806 |
| Orange | 9 | not reported (high-noise figure) |
Orange County's employee total was published but flagged high-noise: the Census Bureau's confidentiality noise moved it by 5% or more. Pinellas has fewer plants than Miami-Dade but more jobs, so its sites are larger.
FDA's register for Florida
FDA's Drug Establishments Current Registration Site (DECRS) lists establishments that manufacture, prepare, propagate, compound or process drugs for the US market. Counting the file we downloaded on 30 October 2026:
| Registered drug establishments in Florida | Count |
|---|---|
| All registrations | 309 |
| List manufacturing or API manufacturing | 218 |
| of which medical gas suppliers (our count by firm name) | 40 |
| of which API manufacturing | 12 |
| Pack, label, repack or relabel only | 56 |
| Testing (analysis) only | 18 |
| PET drug production only | 9 |
| Other (medicated feed, gas transfill, distribution, particle size) | 8 |
Miami has the most registrations (34), then Tampa (22), Orlando (16), Boca Raton and Jacksonville (10 each). Registrants include Noven Pharmaceuticals (Miami), Catalent Pharma Solutions (St. Petersburg), B. Braun US Pharmaceutical Manufacturing (Daytona Beach), Lonza Tampa, Actavis Laboratories FL (Davie and Sunrise), Bausch & Lomb (Tampa), ADMA Biologics (Boca Raton), Alchem Laboratories (Alachua) and Pegasus Laboratories (Pensacola). Others include home medical equipment suppliers registered for oxygen and small makers of topical and over-the-counter products. A registration is the company's own filing, not an FDA approval.
Listed drugmakers headquartered in Florida
SEC EDGAR shows 47 listed companies in SIC codes 2833 to 2836 with a Florida business address. The two largest by revenue, Trulieve and Jushi, are cannabis operators, so they're left out. The drugmakers, checked in each latest 10-K:
| Company | Headquarters (10-K cover) | Revenue, 2025 | Employees reported |
|---|---|---|---|
| OPKO Health (diagnostics and pharmaceuticals) | Miami | $606.9 million | 2,275 full-time |
| Ligand Pharmaceuticals | Jupiter | $268.1 million | 47 full-time |
| Fortress Biotech | Bay Harbor Islands | $63.3 million | 78 full-time, including subsidiaries |
| Sunshine Biopharma | Fort Lauderdale | $36.3 million | 50 full-time |
| Dyadic International | Jupiter | $3.1 million | 5 full-time |
| TherapeuticsMD | Boca Raton | $3.0 million | not stated |
| Longeveron | Miami | $1.2 million | 37 full-time |
Ligand's EDGAR record still shows San Diego, but its 10-K cover gives 555 Heritage Drive, Jupiter. Veru (Miami) and AIM ImmunoTech (Ocala) are also listed drug developers headquartered in the state. For context on the biggest drugmakers worldwide, see the largest pharmaceutical companies.
Florida's permits
Florida regulates drug businesses under Chapter 499 of its statutes, the Florida Drug and Cosmetic Act. Section 499.01 says a permit is required "for each person and establishment" before it operates as, among 18 types:
| Permit type | Who needs it |
|---|---|
| Prescription drug manufacturer or repackager | Plants and repackagers in Florida |
| Nonresident prescription drug manufacturer | Out-of-state makers shipping into Florida |
| Prescription drug wholesale distributor | Distributors based in Florida |
| Over-the-counter drug manufacturer | OTC makers, such as sunscreen and topical products |
| Third party logistics provider | Warehouses handling drugs for others |
FDA lists the Florida Department of Business and Professional Regulation as the agency that licenses wholesale distributors, and its license search lets you look up a permit by type. Check FDA's Data Dashboard for inspections, warning letters and recalls before you sign anything, and use BioFlorida, the state's life sciences association, for events and introductions.
If you're looking for work, the size table matters most: with 117 of 184 plants under 20 employees, most openings are at small, owner-run firms, and the state's average pay in the industry is well below the national leaders.
Prospecting Florida drug companies
| Segment | How to find them | Who decides |
|---|---|---|
| Larger plants (27 with 100 or more staff) | DECRS manufacturing registrations in Pinellas, Broward and Palm Beach | Site director, quality and engineering |
| Small and OTC manufacturers (117 under 20 staff) | DECRS plus Florida's OTC manufacturer permits | The owner or general manager |
| Repackagers and labelers (56 registrations) | DECRS pack and label operations | Operations manager or owner |
| Wholesalers and 3PLs (864 establishments) | Florida's wholesale distributor and 3PL permits | Compliance officer and warehouse manager |
Worked example: a label and carton printer
Illustrative example. The printer and its prices are invented; the counts come from FDA's registration file.
Gulf Coast Labels (gulfcoastlabels.example) prints compliant labels and cartons for drug packagers.
- Build the list. 178 manufacturing registrations that aren't gas suppliers, plus 56 pack and label sites: 234 sites.
- Do the arithmetic. Reaching the owner or operations manager at half gives 117 conversations. If 10% ask for a quote, that's 12, and if 5 become customers at $24,000 a year, $120,000.
- Sequence by county. Start in Miami-Dade, Broward and Palm Beach, where 88 of the plants are, then Tampa Bay.
For a list this long, research is the bottleneck; Bebop researches each company in a list and suggests the right contact.
Subject: Label changeovers at [company] Hi [first name], [Company] is registered with FDA to [pack / label / repack] at its [town] site. Packagers we work with in Florida say artwork changes, not press time, are what delay a run. We print compliant drug labels and cartons in South Florida with proofs in 24 hours. Would it help if I sent a sample pack and our changeover checklist? [Your name] [Phone number]
Next step: compare a state with fewer, larger plants in the Michigan pharmaceutical market report.
Sources
- County Business Patterns (CBP), 2023, US Census Bureau, accessed 30 October 2026
- 2023 County Business Patterns datasets (state and county files, NAICS 3254, 424210 and 541714), US Census Bureau, accessed 30 October 2026
- Drug Establishments Current Registration Site (DECRS), US Food and Drug Administration, accessed 30 October 2026
- DECRS annual registration status download (drls_reg.zip), US Food and Drug Administration, accessed 30 October 2026
- Florida Statutes, section 499.01: Permits, The Florida Legislature, accessed 30 October 2026
- Check licensure of wholesale drug distributors and third-party logistics providers, US Food and Drug Administration, accessed 30 October 2026
- License search by type, Florida Department of Business and Professional Regulation, accessed 30 October 2026
- FDA Data Dashboard, US Food and Drug Administration, accessed 30 October 2026
- OPKO Health Form 10-K for 2025, OPKO Health, Inc., via SEC EDGAR, filed 26 February 2026
- Ligand Pharmaceuticals Form 10-K for 2025, Ligand Pharmaceuticals Incorporated, via SEC EDGAR, filed 27 February 2026
- Fortress Biotech Form 10-K for 2025, Fortress Biotech, Inc., via SEC EDGAR, filed 31 March 2026
- Sunshine Biopharma Form 10-K for 2025, Sunshine Biopharma Inc., via SEC EDGAR, filed 3 April 2026
- Dyadic International Form 10-K for 2025, Dyadic International, Inc., via SEC EDGAR, filed 25 March 2026
- TherapeuticsMD Form 10-K for 2025, TherapeuticsMD, Inc., via SEC EDGAR, filed 30 March 2026
- Longeveron Form 10-K for 2025, Longeveron Inc., via SEC EDGAR, filed 17 March 2026
- Trulieve Cannabis Form 10-K for 2025, Trulieve Cannabis Corp., via SEC EDGAR, filed 26 February 2026
- BioFlorida, BioFlorida, accessed 30 October 2026
Written by the Bebop team at Blackpearl Group. Published .
Questions people ask
How many pharmaceutical companies are in Florida?
Census County Business Patterns counted 184 pharmaceutical and medicine manufacturing establishments in Florida in 2023, with 9,967 employees, the third most establishments of any state. FDA's drug establishment registration file lists 309 registered sites in Florida, including packagers, testing labs and medical gas suppliers. The state also has 864 drug wholesale establishments, which the Census Bureau counts separately.
What pharmaceutical companies are headquartered in Florida?
Listed drugmakers whose latest 10-K gives a Florida headquarters include OPKO Health (Miami, $606.9 million of 2025 revenue), Ligand Pharmaceuticals (Jupiter, $268.1 million), Fortress Biotech (Bay Harbor Islands), Sunshine Biopharma (Fort Lauderdale), Dyadic International (Jupiter), TherapeuticsMD (Boca Raton) and Longeveron (Miami). Larger plants owned by companies based elsewhere include Catalent in St. Petersburg and B. Braun in Daytona Beach.
Do you need a permit to make or distribute drugs in Florida?
Yes. Section 499.01 of the Florida Statutes requires a permit before a person or establishment operates as a prescription drug manufacturer, repackager, wholesale distributor, over-the-counter drug manufacturer, third party logistics provider or one of 13 other listed types. FDA lists the Florida Department of Business and Professional Regulation as the agency that licenses wholesale distributors.
How much do pharmaceutical manufacturing jobs pay in Florida?
Pharmaceutical and medicine manufacturing establishments in Florida paid $724.6 million to 9,967 employees in 2023, an average of $72,704 a year, according to Census County Business Patterns. That's lower than in New Jersey ($103,623) or Massachusetts ($152,661), partly because Florida's plants are smaller: 117 of 184 have fewer than 20 employees.